On the cover this week, authors of a new letter argue that global science can serve as a foundation for international cooperation, even when politics fails. Read this & more: spkl.io/60197RSYL

In @TheLancetNeuro, a new Series explores how Alzheimer's disease clinical practice might evolve over the next 5–10 years, focusing on: ➡️ fluid biomarkers ➡️ neuroimaging ➡️ clinical pathways for cognitively unimpaired individuals Read now: spkl.io/60107R5sk

New in a series of cases in global social medicine: "Disability expertise: a paediatrician with cerebral palsy in Japan" Read now: spkl.io/60117uqmz

🆕 The Lancet Regional Health - Eastern Mediterranean has published its first piece of content online. Farida Abougaziaa & Mohamed Salama discuss the overlooked mental health needs of older refugees in Egypt and the broader Eastern Mediterranean Region: spkl.io/60187RVvwMostrar mais

Meet Suzette Delaloge, medical oncologist and researcher at Gustave Roussy. Join her as she opens the inaugural Gustave Roussy–Lancet Lecture and takes part in a panel discussion on personalised cancer prevention. 👉 spkl.io/60187yTr2

Uptake of robotic-arm-assisted total knee replacement is increasing rapidly worldwide. Yet whether robotic systems improve outcomes after TKR is uncertain. A new study investigated the clinical efficacy and cost-effectiveness of Mako robotic-arm-assisted TKR versus TKR with conv…Mostrar mais

According to a new analysis published in @TheLancetPH, more than 2.7 billion people were exposed to second-hand smoke in 2023, contributing to nearly 1.7 million deaths. Explore the research 👉 spkl.io/60187uhg2 #GBD @IHME_UW

Stereotactic body radiation therapy (SBRT) is the standard of care for early-stage, medically inoperable non-small-cell lung cancer (NSCLC). A new trial investigated the addition of neoadjuvant, concurrent, and adjuvant atezolizumab with SBRT: www.thelancet.com/journals/lancet/article/...…Mostrar mais

In The Lancet Surgery & Anaesthesiology, Debra Leung and colleagues explore perioperative shared decision making through a global equity lens. Read now: spkl.io/60117uqmh

How will the Meta settlement affect child health? Find out more in a new World Report: spkl.io/60107uWVG

"So, should you be optimistic about the future of @WHO? You have to be. There is no other choice." In a new Offline, Richard Horton discusses the current challenges facing the WHO and its upcoming leadership transition. Read now: spkl.io/60137uWDP

What we eat, where we live and how we work have long been understood as determinants of health. But what we scroll, what algorithms feed us and how platforms are designed are determinants of health too. Join us and DTH-Lab for the launch of a new Lancet Series. October 5, 13:00…Mostrar mais

"...cardiovascular health should be central to maternal care." Our latest Editorial discusses cardiovascular health challenges during pregnancy and the need for better preventive care. Read now: spkl.io/60187umUj

🫀 What excited us at #ESCCongress? Hear Lancet editors discuss the most interesting sessions, areas to watch, and the status of AI in cardiology right now. spkl.io/60177ummD

Cardiovascular disease is one of the leading causes of maternal mortality & a major driver of morbidity. In our latest issue, a new Lancet Series examines the continuum of cardiovascular risk surrounding pregnancy. Read this & more: spkl.io/60197umRf

A new Clinical Rounds article emphasizes the importance of resisting cognitive bias in cancer patients through reflective reassessment and biopsy confirmation. Read now: spkl.io/60117u9Vh

The Lancet Surgery & Anaesthesiology has published its first piece of content online 📝 Ntuli Kapologwe & colleagues highlight the importance of global surgery to global health and the need for synergy between the @WHO ECO Strategy & NSOAPS. Read now: spkl.io/60197uG9DMostrar mais

🎧 What cardiovascular issues can women experience in pregnancy, and why? Lancet editors Niall Boyce and Chloe Wilson talk with Professor Garima Sharma, one of the authors of a new Series of papers aiming to bring the cardiovascular health of pregnant women into the mainstream of…Mostrar mais

Atopic dermatitis is a common, chronic, inflammatory skin disease that is challenging to treat. A new study investigated the efficacy and safety of rezpegaldesleukin in adults with moderate-to-severe atopic dermatitis: spkl.io/60157PgrD

There is no clear standard of care for patients with advanced renal cell carcinoma after immune checkpoint inhibitor-based therapy. A recent study established belzutifan–lenvatinib as a potential treatment option in that patient group. Read more: spkl.io/60107PkWa

Presented at #ESCCongress—Targeted left ventricular lead placement in biventricular pacing for heart failure: a national, multicentre, doubleblind, randomised controlled trial in Denmark spkl.io/60147P002

Presented at #ESCCongress—Targeted left ventricular lead placement in biventricular pacing for heart failure: a national, multicentre, doubleblind, randomised controlled trial in Denmark spkl.io/60127PYMG

Presented at #ESCCongress: New study offers contemporary assessment of the changing aetiological profile, management, and outcomes of acute heart failure in Africa. THESUS-HF II comprises more than 1500 patients from 17 African countries. spkl.io/60137Px2V

Presented at #ESCCongress: one of the largest contemporary multicountry studies of acute heart failure conducted in Africa to date. Its findings cautiously suggests an evolving aetiological profile. Patients continue to present at a relatively young age. Read more:

Islatravir–lenacapavir has potential to be the first once-weekly complete oral single-tablet regimen for HIV-1 treatment, suggests ISLEND-2 trial in The Lancet. Explore the research: spkl.io/60117PkuN

Cardiovascular disease is one of the leading causes of maternal mortality & a major driver of morbidity. Yet pregnancy-related cardiovascular complications are often under-recognised & variably managed. A new Lancet Series examines the continuum of cardiovascular risk surroundin…Mostrar mais

Guidelines recommend catheter ablation for symptom relief in patients with atrial fibrillation. In this study, catheter ablation did not demonstrate superiority over a sham procedure for improving atrial fibrillation-related quality of life at 6 months: www.thelancet.com/journals/lancet/article/...…Mostrar mais

Physiotherapist-led care for musculoskeletal conditions in the emergency department (RESHAP-ED): a randomised controlled trial with economic evaluation spkl.io/60167PgH4

In the context of patients with suspected myocardial infarction, implementing the 0/1-hour pathway met non-inferiority criterion for safety but did not shorten emergency department length of stay compared with the 0/3 h pathway, suggests new study. Presented at #ESCCongress:

Pre-eclampsia continues to contribute substantially to perinatal morbidity and mortality, affecting up to 8% of pregnancies worldwide. A new Seminar summarises current clinical and biomedical concepts related to pre-eclampsia, major advancements, and remaining knowledge gaps:

Elevated serum lipoprotein(a) is a causal risk factor for atherosclerotic cardiovascular disease and aortic stenosis. Presented at #ESCCongress, this study of Kylo-11—a very long-acting small interfering RNA targeting lipoprotein(a)—supports future phase 2 and 3 trials.

Advances in biotechnology offer huge opportunities for early disease detection and therapy and vaccine development. At the same time, inadvertent or deliberate misuse carries catastrophic health risks. How do we balance the two? Find out more: spkl.io/60117P54b

The lessons from past Ebola outbreaks are well known. The challenge is putting them into practice. A new Comment calls for communities and civil society to have greater agency in shaping outbreak responses—not simply receiving them. Read this & more: spkl.io/60147P5nmMostrar mais

MASLD is the most common type of long-term liver disease globally. Diagnoses of MASLD in UK general practice have risen almost five-fold in a decade, but most cases are still going unrecorded, suggests study in @LancetRH_Europe: spkl.io/60127PVwa

Out now: the first issue of The Lancet Medical Imaging & Theranostics ⤵️ “Together with you…we can lead imaging forward into a future where we see further and more clearly than ever before.” Explore the issue: spkl.io/60197PXx5 #goldopenaccess

“My doctor told me to lose weight.” In a new essay, Lauren Hartman examines the unintended consequences that weight-focused conversations can have for young people—and calls for a more nuanced approach to health beyond weight and BMI. Read now: spkl.io/60107PBm8

🚨 There is still time to register for @eClinicalMed's webinar "Transforming the Landscape of #GynaecologicalCancer: Advances in Prevention, Precision Surgery, and Innovative Systemic Therapies". Register now: spkl.io/60157OART Read the Series: spkl.io/60167OARp

More than 1 billion people are estimated to have a disability worldwide. To support a more inclusive research process & better evidence generation for people with disabilities, we updated our information for authors to include reporting on disability. Find out more:

Uptake of robotic-arm-assisted total knee replacement is increasing rapidly worldwide. Yet whether robotic systems improve outcomes after TKR is uncertain. A new study investigated the clinical efficacy and cost-effectiveness of Mako robotic-arm-assisted TKR versus TKR with conv…Mostrar mais

Could heart bypass surgery avoid opening the breastbone? In the MIST trial, selected patients receiving minimally invasive coronary artery bypass grafting (CABG) reported better physical recovery at one month than those receiving sternotomy CABG. Read more:

Hepatocellular carcinoma is the main pathological type of liver cancer. A new study investigated whether liver resection can provide survival benefit in patients with advanced hepatocellular carcinoma who respond to systemic therapy: spkl.io/60107OwNG

Bloodstream-delivered cell therapy slows muscle decline in young people with Duchenne muscular dystrophy, phase 3 trial finds. Explore the research 👉 spkl.io/60137OMrW

Irritable bowel syndrome (IBS) affects 5–10% of people worldwide, and has a substantial impact on quality of life. In @LancetGastroHep, a Review discusses the current understanding of IBS in terms of peripheral, central, and integrated mechanisms ▶️ spkl.io/60167OO0G

Psoriasis is a common, chronic skin disease affecting more than 60 million individuals worldwide. In a Seminar, authors provide an updated survey of current knowledge on psoriasis, its clinical management, and key future challenges: spkl.io/60177OMRc

In people with type 2 diabetes, once-daily oral zenagamtide showed clinically meaningful and significant improvements in glycated haemoglobin (HbA1c) compared with placebo at three dose levels, study finds. Find out more: spkl.io/60147ObcG

On the cover this week, a new Editorial examines the deteriorating state of LGBTQ+ rights globally and its implications on health. Read this & more: spkl.io/60107OnLC

We're inviting submissions for the 2025 #WakleyPrize Essay Competition. ✍️ Explore this year's theme, put pen to paper, and submit your work today: spkl.io/60137OOs7

The Lancet's annual Highlights photography competition is open for submissions. 📷 We invite original photographs that capture the realities of health—from clinical care and community action to resilience, compassion, and hope. Find out more ➡️ spkl.io/601573aMf

Our Clinical Resources hub is designed with clinicians in mind — clear, logical, and packed with the latest research. Discover how it can support your practice: spkl.io/60167zgXw

Read the latest #Ebola research, reviews, and commentaries published across The Lancet Group, free to access. Visit the Lancet Ebola Collection: spkl.io/601278pkK